I am currently a postdoctoral researcher in the Biochemistry Department at the University of Oxford. My work is jointly advised by Professor Mark Sansom and Dr. Phill Stansfeld and funded by the BBSRC. Before coming to Oxford, I held postdoctoral position with Professor Zan Luthey-Schulten in the Department of Chemistry at the University of Illinois at Urbana-Champaign (UIUC). In December 2016, I received my Ph. D. in Physics from UIUC under the guidance of the late Professor Klaus Schulten at the NIH Center for Biomolecular Modeling and Bioinformatics. My work focuses on the use of atomistic molecular dynamics simulations to investigate the structure and function of large, biomolecular complexes. I’m especially interested in the physical mechanisms of biological information processing within bacterial chemotaxis.
Below are listed selected publications and presentations associated with my research.
Publications
- CryoEM-based Hybrid Modeling Approaches for Structure Determination
Cassidy C.K., Himes B.A., Luthey-Schulten Z., Zhang P., Current Opinion in Microbiology, 2017, Accepted
- GPU-accelerated molecular dynamics clustering analysis with openACC
Stone J.E., Perilla J.R., Cassidy C.K., Schulten K., In Parallel Programming with openACC, Elsevier, 2016
- CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling
*Cassidy C.K., *Himes B.A., *Alvarez J.A., Ma J., Zhao G., Perilla J.R., Schulten K., Zhang P., eLife, 2015
In the news: Researchers resolve structure of a key component of bacterial decision-making
PDB: 3JA6
EMDB: 6319, 6320
- Computational Methodologies for Real-Space Structural Refinement of Large Macromolecular Complexes
Goh B.C., Hadden J.A., Bernardi R.C., Singharoy A., McGreevy R., Rudack T., Cassidy C.K., Schulten K., Annual Review of Biophysics, 45:253-278, 2016
- Molecular dynamics simulations of large macromolecular complexes
Perilla J.R., Goh B.C., Cassidy C.K., Liu B., Bernardi R.C., Rudack T., Yu H., Wu Z., and Schulten K., Current Opinion in Structural Biology, 31:64-74, 2015
- CheY’s acetylation sites responsible for generating clockwise flagellar rotation in Escherichia coli
Fraiberg M., Afanzar O., Cassidy C.K., Gabashvili A., Schulten K., Levin Y., Eisenbach M., Molecular Microbiology, 95:231-244, 2015
Presentations
Modeling and Simulation of the Bacterial Chemosensory Array
- Biochemistry Seminar. 2017. Oxford University, Oxford, England (Invited Talk)
- Biology Seminar. 2017. Leiden University, Leiden, Netherlands (Invited Talk)
- Receptor Fest 20th Annual Meeting. 2017. Salt Lake City, Utah (Talk)
- Blue Waters Annual Symposium. 2017. Sunriver, Oregon (Video of Talk)
- Receptor Fest 19th Annual Meeting. 2016. Santa Barbara, California (Talk)
- Gordon Research Conference: Sensory Transduction in Microorganisms. 2016. Ventura Beach, California (Invited Talk)
- Gordon Research Seminar: Sensory Transduction in Microorganisms. 2016. Ventura Beach, California (Poster)
- Medical Microbiology and Immunology Seminar. 2015. University of Wisconsin, Madison (Invited Talk)
- Receptor Fest 18th Annual Meeting. 2015. Boulder, Colorado (Talk)
- Biophysical Society 59th Annual Meeting. 2015. Baltimore, Maryland (Poster)
- Bacterial Signaling and Locomotion XIII. 2015. Tucson, Arizona (Invited Talk)
- Receptor Fest 17th Annual Meeting. 2014. Salt Lake City, Utah (Talk)
- Blue Waters Annual Symposium. 2014. Urbana, Illinois (Talk)
- Biophysical Society 58th Annual Meeting. 2014. San Francisco, California (Poster)
- SOPS 4th Annual Postdoctoral Research Symposium. 2014. Urbana, Illinois (Poster)
- Beckman Institute Graduate Student Seminar. 2013. Urbana, Illinois (Talk)
