I am currently a postdoctoral researcher in the Biochemistry Department at the University of Oxford. My work is jointly advised by Professor Mark Sansom and Dr. Phill Stansfeld and funded by the BBSRC. Before coming to Oxford, I held a postdoctoral position with Professor Zan Luthey-Schulten in the Department of Chemistry at the University of Illinois at Urbana-Champaign (UIUC). In December 2016, I received my Ph. D. in Physics from UIUC under the guidance of the late Professor Klaus Schulten at the NIH Center for Biomolecular Modeling and Bioinformatics. My work focuses on the use of atomistic molecular dynamics simulations to investigate the structure and function of large, biomolecular complexes. I’m especially interested in the physical mechanisms of biological information processing within bacterial chemotaxis.

Below are listed selected publications and presentations associated with my research.

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Publications

• In situ conformational changes of the Escherichia coli serine chemoreceptor in different signaling states. Yang W., Cassidy C.K., Ames P., Diebolder C.A., Schulten K., Luthey-Schulten Z., Parkinson J.S., Briegel A. mBio, 2019, In press.

• CryoEM-based hybrid modeling approaches for structure determination. Cassidy C.K., Himes B.A., Luthey-Schulten Z., Zhang P., Current Opinion in Microbiology, 2018

• GPU-accelerated molecular dynamics clustering analysis with openACC. Stone J.E., Perilla J.R., Cassidy C.K., Schulten K., In Parallel Programming with openACC, Elsevier, 2016

• CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling. *Cassidy C.K., *Himes B.A., *Alvarez J.A., Ma J., Zhao G., Perilla J.R., Schulten K., Zhang P., eLife, 2015

  • In the news: Researchers resolve structure of a key component of bacterial decision-making

  • PDB: 3JA6; EMDB: 6319, 6320

• Computational methodologies for real-space structural refinement of large macromolecular complexes. Goh B.C., Hadden J.A., Bernardi R.C., Singharoy A., McGreevy R., Rudack T., Cassidy C.K., Schulten K., Annual Review of Biophysics, 45:253-278, 2016

• Molecular dynamics simulations of large macromolecular complexes. Perilla J.R., Goh B.C., Cassidy C.K., Liu B., Bernardi R.C., Rudack T., Yu H., Wu Z., and Schulten K., Current Opinion in Structural Biology, 31:64-74, 2015

• CheY’s acetylation sites responsible for generating clockwise flagellar rotation in Escherichia coli. Fraiberg M., Afanzar O., Cassidy C.K., Gabashvili A., Schulten K., Levin Y., Eisenbach M., Molecular Microbiology, 95:231-244, 2015

  • Extra: Selected for Faculty of 1000 Prime

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Presentations

• Receptor Fest 22nd Annual Meeting. 2019. University of Oregon, Eugene, Oregon (Talk)
• Receptor Fest 21st Annual Meeting. 2018. Cornell University, Ithaca, New York (Talk)
• Biochemistry Seminar. 2017. Oxford University, Oxford, England (Invited Talk)
• Biology Seminar. 2017. Leiden University, Leiden, Netherlands (Invited Talk)
• Receptor Fest 20th Annual Meeting. 2017. University of Utah, Salt Lake City, Utah (Talk)
• Blue Waters Annual Symposium. 2017. Sunriver, Oregon (Video of Talk)
• Receptor Fest 19th Annual Meeting. 2016. University of California Santa Barbara, Santa Barbara, California (Talk)
• Gordon Research Conference: Sensory Transduction in Microorganisms. 2016. Ventura Beach, California (Invited Talk)
• Gordon Research Seminar: Sensory Transduction in Microorganisms. 2016. Ventura Beach, California (Poster)
• Medical Microbiology and Immunology Seminar. 2015. University of Wisconsin, Madison (Invited Talk)
• Receptor Fest 18th Annual Meeting. 2015. University of Colorado, Boulder, Colorado (Talk)
• Biophysical Society 59th Annual Meeting. 2015. Baltimore, Maryland (Poster)
• Bacterial Signaling and Locomotion XIII. 2015. Tucson, Arizona (Invited Talk)
• Receptor Fest 17th Annual Meeting. 2014. University of Utah, Salt Lake City, Utah (Talk)
• Blue Waters Annual Symposium. 2014. Urbana, Illinois (Talk)
• Biophysical Society 58th Annual Meeting. 2014. San Francisco, California (Poster)
• SOPS 4th Annual Postdoctoral Research Symposium. 2014. Urbana, Illinois (Poster)
• Beckman Institute Graduate Student Seminar. 2013. Urbana, Illinois (Talk)